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Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 319-332 doi: 10.1007/s11684-017-0569-9

Abstract: this review, we highlight the new molecular insights about the pathogenesis of DN from the aspects of immuneinflammation response, epithelial–mesenchymal transition, apoptosis and mitochondrial damage,

Keywords： diabetic nephropathy     immune inflammatory response     epithelial–mesenchymal transition     apoptosis     mitochondrial    

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Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 816-819 doi: 10.1007/s11684-020-0823-4

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Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used forThe impact of LDT on the response to systemic treatment is unknown.A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were includedData were analyzed for response to treatment, progression-free survival (PFS), and overall survival (The objective response rate to any ICB (16.7% vs. 3.8%, P =

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 1-5 doi: 10.1007/s11684-014-0309-3

Abstract: instance, fever-range temperature (39β°C to 40β°C) can modulate the activities of immuneCytotoxic temperature (>43β°C) can create an antigen source to induce an anti-tumor immuneresponse.

Keywords： hyperthermia     HPV     immune response     virus     tumor    

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Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric

Jianpeng Liu, Xinhua Chen, Shusen Zheng

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 170-177 doi: 10.1007/s11684-020-0747-z

Abstract: nsPEF can induce the immunogenic cell death of hepatocellular carcinoma (HCC) and stimulate the host’s immuneresponse to kill residual tumor cells and decrease distant metastatic tumors. nsPEF-induced immunityis of great clinical importance because the nonthermal ablation may enhance the immune memory, whichwere illustrated. nsPEF stimulates the host immune system to boost stimulation and prevail suppressionnsPEF increases the dendritic cell loading and inhibits the regulatory responses, thereby improving immune

Keywords： nanosecond pulsed electric fields (nsPEF)     hepatocellular carcinoma (HCC)     immune response     recurrence     metastasis    

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Integrated analysis of gut microbiome and host immune responses in COVID-19

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 263-275 doi: 10.1007/s11684-022-0921-6

Abstract: Emerging evidence indicates that the gut microbiome contributes to the host immune response to infectiousHere, to explore the role of the gut microbiome in the host immune responses in COVID-19, we conductedshotgun metagenomic sequencing and immune profiling of 14 severe/critical and 24 mild/moderate COVIDTogether, our study highlighted a potential regulatory role of severity related gut microbes in the immuneresponse of host.

Keywords： COVID-19     SARS-COV-2     gut microbiome     immune response    

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Universal influenza virus vaccines: what can we learn from the human immune response following exposure

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 471-479 doi: 10.1007/s11684-017-0602-z

Abstract: Here we review what is known about the human humoral immune response to vaccination and infection with

Keywords： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 173-186 doi: 10.1007/s11684-015-0384-0

Abstract:

Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), serving as the main mechanism by which metformin improves hyperglycemia of T2D. Biochemically, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D. These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty liver disease. As supported by the results from both human and animal studies, metformin improves hepatic steatosis and suppresses liver inflammation. Mechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases.

Keywords： metformin     diabetes     hepatic steatosis     inflammatory response     insulin resistance    

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Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 95-99 doi: 10.1007/s11684-008-0017-y

Abstract: had a high specificity against mouse-anti-Sj14-3-3 monoclonal antibody and rSj14-3-3 had a promising immune

Keywords： development     challenging     rSj14-3-3     resistance     cultural supernatant    

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Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 390-395 doi: 10.1007/s11684-009-0087-5

Abstract: It was employed to evaluate immune response of the mice inoculated doubly with the DNA vaccine.In conclusion, the EBV DNA vaccine can induce a strong humoral immune response in mice.

Keywords： Epstein-Barr virus     latent membrane protein 2     nasopharyngeal carcinoma     humoral immunity    

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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 726-745 doi: 10.1007/s11684-020-0746-0

Abstract: Mobilization of endogenous immune cells is also necessary for CAR T cells to obtain their optimal therapeuticeffect given the importance of the innate immune responses in the elimination of malignant tumors.this review, we focus on the recent advances in the engineering of CAR T cell therapies to restore the immuneresponse in solid malignancies, especially with CAR T cells acting as cellular carriers to deliver immunomodulatorsto tumors to mobilize the endogenous immune response.

Keywords： CAR T cells     immunoregulatory molecules     endogenous immune response     solid malignancies    

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: Carboplatin in TNBC (DETECT) trial (NCT03295552), decitabine with carboplatin produced an objective responseIn the DETECT trial, decitabine induced strong immune responses featuring the striking upregulation ofthe innate immune player IRF7 in the p53-mutated TNBC cell line (upregulation by 16-fold) and

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 195-203 doi: 10.1007/s11684-012-0189-3

Abstract:

The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofenThe anti-inflammatory effect of SDBT was evaluated using the mouse ear edema test with xylene.SDBT displayed more significant anti-inflammatory effects than CT.The dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea

Keywords： ibuprofen     solid dispersion     physical mixture     dissolution     anti-inflammatory effect    

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Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 139-145 doi: 10.1007/s11684-015-0377-z

Abstract: view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatoryarticle, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatoryIL-15 expression is induced in immune cells by endotoxin and in muscle cells by physical exercise.In the immune system, IL-15 stimulates proliferation and differentiation of T cells, NK cells, monocytesIn summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance

Keywords： inflammation     obesity     cytokine     energy expenditure     insulin resistance    

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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 480-489 doi: 10.1007/s11684-017-0594-8

Abstract: This observation indicates that the immune responses elicited by natural HIV-1 infection may play a roleThus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses thanimmunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune

Keywords： human immunodeficiency virus type I     superinfection     incidence     immune response    

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Title Author Date Type Operation

Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Journal Article

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Journal Article

Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Journal Article

Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Journal Article

Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric

Jianpeng Liu, Xinhua Chen, Shusen Zheng

Journal Article

Integrated analysis of gut microbiome and host immune responses in COVID-19

Journal Article

Universal influenza virus vaccines: what can we learn from the human immune response following exposure

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Journal Article

Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Journal Article

Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Journal Article

Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Journal Article

Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen

Journal Article

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Journal Article

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Journal Article